Multi-kinase inhibitor I
CAS No. 778274-97-8
Multi-kinase inhibitor I ( MDK74978 | MDK 74978. Multi-kinase inhibitor I )
产品货号. M17593 CAS No. 778274-97-8
多激酶抑制剂 I 是一种多激酶抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
5MG | ¥616 | 有现货 |
|
10MG | ¥988 | 有现货 |
|
25MG | ¥2001 | 有现货 |
|
50MG | ¥3216 | 有现货 |
|
100MG | ¥4771 | 有现货 |
|
200MG | 获取报价 | 有现货 |
|
500MG | 获取报价 | 有现货 |
|
1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称Multi-kinase inhibitor I
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述多激酶抑制剂 I 是一种多激酶抑制剂。
-
产品描述MDK74978, also known as Multi-kinase inhibitor I, is a Multi-kinase inhibitor. MDK74978 has CAS#778274-97-8. The last 5 digit was used in its name.
-
体外实验Multi-kinase inhibitor 1 (compound 68) is a potent multi-kinase inhibitor. The protein kinases represent a large family of proteins, which play a central role in the regulation of a wide variety of cellular processes and maintaining control over cellular function. These kinases include receptor tyrosine kinases, such as platelet derived growth factor receptor kinase(PDGF-R), the receptor kinase for stem cell factor, c-Kit, and non-receptor tyrosine kinases, such as the fusion kinase Bcr-abl.
-
体内实验——
-
同义词MDK74978 | MDK 74978. Multi-kinase inhibitor I
-
通路Angiogenesis
-
靶点HIF/HIF Prolyl-hydroxylase
-
受体Multi-kinase
-
研究领域——
-
适应症——
化学信息
-
CAS Number778274-97-8
-
分子量418.38
-
分子式C20H17F3N4O3
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (239.02 mM)
-
SMILESO=C(NCCO)c1ccc(c2ncnc(Nc3ccc(OC(F)(F)F)cc3)c2)cc1
-
化学全称N-(2-Hydroxyethyl)-4-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Chang Hsu Y, et al. Oncotarget. 2016 Nov 15
产品手册
关联产品
-
DM-NOFD
N-草酰-d-苯丙氨酸 (NOFD) 的二甲酯,一种特定的 HIF 天冬酰胺酰羟化酶 (FIH) 抑制剂,Ki 为 83 uM。
-
Izilendustat
Izilendustat 是一种有效的脯氨酰羟化酶 (prolyl hydroxylase) 抑制剂,可稳定缺氧诱导因子-1 α (HIF-1α) 和缺氧诱导因子-2 (HIF-2)。Izilendustat 具有研究与身体免疫反应相关的疾病的潜力,如结肠炎和其他炎症性肠病 。
-
JTZ-951
一种新型有效的口服活性 HIF 脯氨酰羟化酶 (PHD) 抑制剂,对 PHD2 的 IC50 为 0.22 uM。